Friday, January 31, 2014 12:00 p.m. ETC 2.136
Professor Christy K. Holland
Department of Internal Medicine and Biomedical Engineering Program
University of Cincinnati
Ultrasound is under development as a potent promoter of beneficial bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, referred to as ultrasound contrast agents, which can also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid motion that affect drug penetration into vascular tissue, lyse thrombi, or direct drugs and bioactive gases to optimal locations for delivery. Ultrasound-triggered release of nitric oxide from echogenic liposomes induces potent vasorelaxation in porcine carotid arteries in an ex vivo system. Recent in vitro and ex vivo data from a variety of clot and vascular models will be discussed.
This acoustics seminar is offered courtesy of the Chevron Centennial Seminar Series in the Department of Mechanical Engineering, and pizza will be served.